Jacques Petzer

Prof
Jacques
Petzer
Drug design and development
Medicinal Chemistry
Pharmaceutical chemistry
Research Professor
Biography
Prof JP Petzer

My research focuses on the rational design, synthesis, and evaluation of novel small molecules targeting complex neuropsychiatric and neurodegenerative disorders. A primary pillar of my work is optimising treatments for central nervous system disorders. For instance, our laboratory has discovered novel agents for the treatment of therapy-resistant depression and Parkinson’s disease, while also developing potent D-amino acid oxidase (DAAO) inhibitors to address the hypofunction of NMDA receptors implicated in schizophrenia. Our group’s core expertise lies in computer-assisted drug design (CADD), chemical synthesis and characterisation of small molecules, and the in vitro evaluation of pharmacological potencies and mechanisms of action.

 

Physical Address

Building G16 Room 213
Potchefstroom Campus

Telephone Number
+27(18) 299 2206
E-mail
jacques.petzer@nwu.ac.za
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Media, links, addresses and key documents
Other Media
  1. Stear, C.; Petzer, A.; Crous, C.; Petzer, J. P., Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase. Med Chem Res 2024, 33 (1), 164-176.
  2. Jacobs, M. E.; Petzer, J. P.; Pretorius, J.; Cloete, S. J.; Crous, C.; Petzer, A., Synthesis and evaluation of 3-hydroxyquinolin-2 (1H)-one derivatives as inhibitors of tyrosinase. Bioorg Med Chem Lett 2024, 109, 129823.
  3. Crous, C.; Petzer, A.; Petzer, J. P., Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data. Chem Biol Drug Des 2024, 103 (2), e14466.
  4. Prinsloo, I. F.; Petzer, J. P.; Cloete, T. T.; Petzer, A., The evaluation of isatin analogues as inhibitors of monoamine oxidase. Chem Biol Drug Des 2023, 102 (5), 1067-1074.
  5. Prinsloo, I. F.; Petzer, A.; Cloete, T. T.; Petzer, J. P., Investigation of the monoamine oxidase inhibition properties of benzoxathiolone derivatives. Med Chem Res 2023, 32 (5), 827-840.
  6. Hitge, R.; Petzer, A.; Petzer, J. P., Isatoic anhydrides as novel inhibitors of monoamine oxidase. Bioorg Med Chem 2022, 73, 117030.
  7. Meiring, L.; Petzer, J. P.; Legoabe, L. J.; Petzer, A., The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett 2022, 67, 128746.
  8. Bester, E.; Petzer, A.; Petzer, J. P., Coumarin derivatives as inhibitors of D-amino acid oxidase and monoamine oxidase. Bioorg Chem 2022, 123, 105791.
  9. Lefin, R.; Petzer, A.; Petzer, J. P., Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase. Bioorg Med Chem 2022, 54, 116558.
  10. De Beer, J.; Petzer, J. P.; Lourens, A. C. U.; Petzer, A., Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase. Mol Divers 2021, 25 (2), 753-762
  11. Hitge, R.; Smit, S.; Petzer, A.; Petzer, J. P., Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase. Bioorg Med Chem Lett 2020, 30 (12), 127188.
  12. de Beer, F.; Petzer, J. P.; Petzer, A., Monoamine oxidase inhibition by selected dye compounds. Chem Biol Drug Des 2020, 95 (3), 355-367.
  13. Prinsloo, D.; van Dyk, S.; Petzer, A.; Petzer, J. P., Monoamine oxidase inhibition by kavalactones from kava (Piper methysticum). Planta Med 2019, 85 (14-15), 1136-1142.
  14. Delport, A.; Harvey, B. H.; Petzer, A.; Petzer, J. P., Methylene blue analogues with marginal monoamine oxidase inhibition retain antidepressant-like activity. ACS Chem Neurosci 2018, 9 (12), 2917-2928.
  15. Delport, A.; Harvey, B. H.; Petzer, A.; Petzer, J. P., Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis 2017, 32 (5), 1357-1382.
  16. Mostert, S.; Petzer, A.; Petzer, J. P., The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase. Eur J Med Chem 2017, 135, 196-203.
  17. Delport, A.; Harvey, B. H.; Petzer, A.; Petzer, J. P., The monoamine oxidase inhibition properties of selected structural analogues of methylene blue. Toxicol Appl Pharmacol 2017, 325, 1-8.
  18. Mostert, S.; Petzer, A.; Petzer, J. P., Inhibition of monoamine oxidase by benzoxathiolone analogues. Bioorg Med Chem Lett 2016, 26 (4), 1200-1204.
  19. Mostert, S.; Petzer, A.; Petzer, J. P., Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase. Chem Biol Drug Des 2016, 87 (5), 737-746.
  20. Petzer, A.; Harvey, B. H.; Petzer, J. P., The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicol Appl Pharmacol 2014, 274 (3), 488-493.